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(Single Best Answer) Question 1: A four year old boy was admitted with a history of abdominal pain and fever for two months, maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination, liver and spleen were enlarged 4 cm and 3 cm respectively below the costal margins. His hemoglobin was 10.0 g/dl, platelet count 37 x 109/L and total leukocyte count 70 x 109/L, which included 80% eosinophils. Bone marrow examination revealed a cellular marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors. The blasts stained negative for myeloperoxidase and non-specific esterase¬ and were positive for CD 19, CD 10, CD22 and CD20. Which one of the following statements in not true about this disease ?
A) Eosinophils are not part of the neoplastic clone
B) t(5; 14) rearrangement may be detected in blasts
C) Peripheral blood eosinophilia may normalize with chemotherapy
D) Inv (16) is often detected in the blasts and the eosinophils
Answer (Select an option above to get the answer):
(Single Best Answer) Question 2: Which of the following statements is not true ?
A) Patiens with IgD myeloma may present with no evident M-spike on serum electrophoresis
B) A diagnosis of plasma cell leukemia can be made if circulating peripheral blood plasmablasts comprise 14% of peripheral blood white cells in a patient with white blood cell count of 11 X 100 /L and platelet count of 88 X 109 /L
C) In smoldering myeloma plasma cells constitute 10 - 30% of total bone marrow cellularity
D) In a patient with multiple myeloma, a monoclonal light chain may be detected in both serum and urine
Answer (Select an option above to get the answer):
(Single Best Answer) Question 3: A 35 yr old female with anemia ,bleeding tendency and with 20% blasts in circulation was diagnosed to have Disseminated Intravascular Coagulation. Most likely etiology in this case is ?
A) Lymphoblastic Leukemia
C) Monocytic Leukemia M5
D) Promyelocytic Leukemia M3
Answer (Select an option above to get the answer):
(Single Best Answer) Question 4: Which of the following is not compatible with a diagnosis of chronic myelomonocytic leukemia ?
A) Peripheral blood monocytosis more than 1 X 109 /L
B) Absence of Philadephia chromosome
C) More than 20% blasts in blood or bone marrow
D) Absent or minimal dysplasia in myeloid lineages
Answer (Select an option above to get the answer):
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