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(Single Best Answer) Question 1: A four year old boy was admitted with a history of abdominal pain and fever for two months, maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination, liver and spleen were enlarged 4 cm and 3 cm respectively below the costal margins. His hemoglobin was 10.0 g/dl, platelet count 37 x 109/L and total leukocyte count 70 x 109/L, which included 80% eosinophils. Bone marrow examination revealed a cellular marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors. The blasts stained negative for myeloperoxidase and non-specific esterase¬ and were positive for CD 19, CD 10, CD22 and CD20. Which one of the following statements in not true about this disease ?
A) Eosinophils are not part of the neoplastic clone
B) t(5; 14) rearrangement may be detected in blasts
C) Peripheral blood eosinophilia may normalize with chemotherapy
D) Inv (16) is often detected in the blasts and the eosinophils
Answer (Select an option above to get the answer):
(Single Best Answer) Question 2: A 48 year old woman was admitted with a history of weakness for two months. On examination, cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5 g/dl, platelet count 237 X 109 / L and total leukocyte count 40 X 109 /L, which included 80% mature lymphoid cells with coarse clumped chromatin. Bone marrow revealed a nodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20, CD23 and were negative for CD79B and FMC-7. The histopathological examination of the lymph node in this patient will most likely exhibit effacement of lymph node architecture by ?
A) A pseudofollicular pattern with proliferation centers
B) A monomorphic lymphoid proliferation with a nodular pattern
C) A predominantly follicular pattern
D) A diffuse proliferation of medium to large lymphoid cells with high mitotic rate
Answer (Select an option above to get the answer):
(Single Best Answer) Question 3: In a patient with acute leukemia Immunophenotype pattern is CD 19+ve, CD 10+ve, CD33+ve, CD13+ve. He may probably have ?
A) Biphenotypic leukemia
Answer (Select an option above to get the answer):
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