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(Single Best Answer) Question 1: A 48 year old woman was admitted with a history of weakness for two months. On examination, cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5 g/dl, platelet count 237 X 109 / L and total leukocyte count 40 X 109 /L, which included 80% mature lymphoid cells with coarse clumped chromatin. Bone marrow revealed a nodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20, CD23 and were negative for CD79B and FMC-7. The histopathological examination of the lymph node in this patient will most likely exhibit effacement of lymph node architecture by ?
A) A pseudofollicular pattern with proliferation centers
B) A monomorphic lymphoid proliferation with a nodular pattern
C) A predominantly follicular pattern
D) A diffuse proliferation of medium to large lymphoid cells with high mitotic rate
Answer (Select an option above to get the answer):
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