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(Single Best Answer) Question 1: A four year old boy was admitted with a history of abdominal pain and fever for two months, maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination, liver and spleen were enlarged 4 cm and 3 cm respectively below the costal margins. His hemoglobin was 10.0 g/dl, platelet count 37 x 109/L and total leukocyte count 70 x 109/L, which included 80% eosinophils. Bone marrow examination revealed a cellular marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors. The blasts stained negative for myeloperoxidase and non-specific esterase¬ and were positive for CD 19, CD 10, CD22 and CD20. Which one of the following statements in not true about this disease ?
A) Eosinophils are not part of the neoplastic clone
B) t(5; 14) rearrangement may be detected in blasts
C) Peripheral blood eosinophilia may normalize with chemotherapy
D) Inv (16) is often detected in the blasts and the eosinophils
Answer (Select an option above to get the answer):
(Single Best Answer) Question 2: A 40-year-old man has a chronic cough with fever for several months. The chest radiograph reveals a diffuse reticulonodular pattern. Microscopically on transbronchial biopsy there are focal areas of inflammation containing epithelioid cell granuloma, Langhans giant cells, and lymphocytes. These findings are typical for which of the following type of hypersensitivity immunologic responses ?
A) Type I
B) Type II
C) Type III
D) Type IV
Answer (Select an option above to get the answer):
(Single Best Answer) Question 3: A adult male patient presented in the OPD with complaints of cough and fever for 3 months and haemoptysis off and on. His sputum was positive for AFB. On probing it was found that he had already received treatment with RHZE for 3 weeks from a nearby hospital and discontinued. How will you categorize and manage the patient ?
A) Category III, start 2 (RHZ)3
B) Category II, start 2 (RHZE)3
C) Category I, start 2 (RHZE)3
D) Category II, start 2 (RHZES)3
Answer (Select an option above to get the answer):
(Single Best Answer) Question 4: Which one of the following is not an adverse effect of ACE inhibitors ?
A) Cough
B) Hypokalemia
C) Angioneurotic oedema
D) Skin rash
Answer (Select an option above to get the answer):
(Single Best Answer) Question 5: A 45 year old coal mine worker presents with cutaneous nodules, joint pain and occasional cough and dyspnoea. His chest radiograph shows multiple small (1-4cms) nodules in bilateral lung fields. Some of the nodules show cavitation and specks of calcification. Most likely these features are diagnostic of ?
A) Sjogrens syndrome
B) Caplan's syndrome
C) Silicosis
D) Wegener's granulomatosis
Answer (Select an option above to get the answer):
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