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(Single Best Answer) Question 1: A four year old boy was admitted with a history of abdominal pain and fever for two months, maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination, liver and spleen were enlarged 4 cm and 3 cm respectively below the costal margins. His hemoglobin was 10.0 g/dl, platelet count 37 x 109/L and total leukocyte count 70 x 109/L, which included 80% eosinophils. Bone marrow examination revealed a cellular marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors. The blasts stained negative for myeloperoxidase and non-specific esterase¬ and were positive for CD 19, CD 10, CD22 and CD20. Which one of the following statements in not true about this disease ?
A) Eosinophils are not part of the neoplastic clone
B) t(5; 14) rearrangement may be detected in blasts
C) Peripheral blood eosinophilia may normalize with chemotherapy
D) Inv (16) is often detected in the blasts and the eosinophils
Answer (Select an option above to get the answer):
(Single Best Answer) Question 2: Which of the following statements pertaining to leukemia is correct ?
A) Blasts of acute myeloid leukemia are typically sudan black negative
B) Blasts of acute lymphoblastic leukemia are typically myeloperoxidase positive
C) Low leucocyte alkaline phosphatase score is characteristically seen in blastic phase of chronic myeloid leukemia
D) Tartarate resistant acid phosphatase positivity is typically seen in hairy cell leukemia
Answer (Select an option above to get the answer):
(Single Best Answer) Question 3: All of the following are mediators of inflammation except ?
A) Tumor necrosis factor - alpha (TNF alpha)
B) Interleukin - 1
C) Myeloperoxidase
D) Prostaglandins
Answer (Select an option above to get the answer):
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