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Phenytoin
(Single Best Answer) Question 1: A patient with recent onset primary generalised epilepsy develops drug reaction and skin rash due to phenytoin sodium. The most appropriate course of action is ?
A) Shift to clonazepam
B) Restart phenytoin sodium after 2 weeks
C) Shift to sodium valproate
D) Shift to ethosuximide
Answer (Select an option above to get the answer):
(Single Best Answer) Question 2: A 30 year old female epileptic on phenytoin, developed weakness and fatigue. Blood examination revealed Hb=4.6 gm, MCV=102fl and MCH=40pg/dL. What is the most probable diagnosis ?
A) Heart failure
B) Iron deficiency Anaemia
C) Phenytoin induced agranulocytosis
D) Megaloblastic anaemia
Answer (Select an option above to get the answer):
(Single Best Answer) Question 3: Therapeutic monitoring is required for all except ?
A) Phenytoin
B) Cyclosporine
C) Tacrolimus
D) Metformin
Answer (Select an option above to get the answer):
(Single Best Answer) Question 4: Phenytoin all are true except ?
A) Induces enzymes
B) Zero order kinetics at low dose
C) Half life increases with increasing dose
D) Highly protein bound
Answer (Select an option above to get the answer):
(Single Best Answer) Question 5: "Torsades de pointes " is seen in ?
A) Quinidine
B) Digoxin
C) Phenytoin
D) Chlorthiazide
Answer (Select an option above to get the answer):
(Single Best Answer) Question 6: True regarding Phenytoin is ?
A) It is not teratogenic
B) It is excreted unchanged
C) It shows Zero order kinetics
Answer (Select an option above to get the answer):
(Single Best Answer) Question 7: OCP fails when used with any of the following except ?
A) Aspirin
B) Phenytoin
C) Rifampicin
D) Tetracycline
Answer (Select an option above to get the answer):
(Single Best Answer) Question 8: False about Antiepileptics is ?
A) Carbamazepine used for Trigeminal Neuralgia
B) Diazepam is anti-epileptic
C) Lamotrigine acts by opening of GABA mediated Cl- channels
D) Phenytoin and Carbamazepine act by prolongation of inactivated state of Na+ Channels
Answer (Select an option above to get the answer):
(Single Best Answer) Question 9: Megaloblastic anaemia may be caused by the following drugs except ?
A) Phenytoin
B) Methotrexate
C) Pyrimethamine
D) Amoxicillin-Clavulanic acid (amoxyclav)
Answer (Select an option above to get the answer):
(Single Best Answer) Question 10: All of the following drugs can induce methaemoglobinaemia, except ?
A) Nitroglycerine
B) Procaine
C) Prilocaine
D) Phenytoin
Answer (Select an option above to get the answer):
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