Read the pedigree. Inheritance pattern of the disease in the family is ?
A) Autosomal recessive type
B) Autosomal dominant type
C) X Linked dominant type
D) X linked recessive type
Answer:
D
Question 2: An example of a tumor suppressor gene is ?
A) myc
B) fos
C) ras
D) Rb
Answer:
D
Question 3: Which on of the following conditions commonly predisposes to colonic carcinoma ?
A) Ulcerative colitis
B) Crohn's disease
C) Diverticular disease
D) Ischaemic colitis
Answer:
A
Question 4: Fibrioid necrosis may be observed in all of the following except ?
A) Malignant hypertension
B) Polyarteritis nodosa
C) Diabetic glomerulosclerosis
D) Aschoff's nodule
Answer:
C
Question 5: All of the following statements are true regarding reversible cell injury, except ?
A) Formation of amorphous densities in the mitochondrial matrix
B) Diminished generation of adenosine triphosphate (ATP)
C) Formation of blebs in the plasma membrane
D) Detachment of ribosomes from the granular endoplasmic reticulum
Answer:
A
Question 6: Which of the following statements pertaining to leukemia is correct ?
A) Blasts of acute myeloid leukemia are typically sudan black negative
B) Blasts of acute lymphoblastic leukemia are typically myeloperoxidase positive
C) Low leucocyte alkaline phosphatase score is characteristically seen in blastic phase of chronic myeloid leukemia
D) Tartarate resistant acid phosphatase positivity is typically seen in hairy cell leukemia
Answer:
D
Question 7: In which of the following conditions bilateral contracted kidneys are characteristically seen ?
A) Amyloidosis
B) Diabetes mellitus
C) Rapidly progressive (crescentic) glomerulonephritis
D) Benign nephroscleorsis
Answer:
D
Question 8: All of the following CSF findings are present in tuberculous meningitis, except ?
A) Raised protein levels
B) Low chloride levels
C) Cob web formation
D) Raised sugar levels
Answer:
D
Question 9: All of the following vascular changes are observed in acute inflammation, except ?
A) Vasodilation
B) Stasis of blood
C) Increased vascular permeability
D) Decreased hydrostatic pressure
Answer:
D
Question 10: The subtype of Hodgkin's disease, which is histogenetically distinct from all the other subtypes, is ?
A) Lymphocyte predominant
B) Nodular sclerosis
C) Mixed cellularity
D) Lymphocyte depleted
Answer:
A
Question 11: In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria ?
A) Bcl-2
B) Bax
C) Bcl-XL
D) Cytochrome C
Answer:
D
Question 12: Which type of amyloidosis is caused by mutation of the transthyretin protein ?
A) Familial Mediterranean fever
B) Familial amyloidotic polyneuropathy
C) Dialysis associated amyloidosis
D) Prion protein assciated amyloidosis
Answer:
B
Question 13: In familial Mediterranean fever, the gene encoding the following protein undergoes mutation ?
A) Pyrin
B) Perforin
C) Atrial natriuretic factor
D) Immunoglobulin light chain
Answer:
A
Question 14: Which of the following statements is not true ?
A) Patiens with IgD myeloma may present with no evident M-spike on serum electrophoresis
B) A diagnosis of plasma cell leukemia can be made if circulating
peripheral blood plasmablasts comprise 14% of peripheral blood white cells in a
patient with white blood cell count of 11 X 100 /L and platelet count
of 88 X 109 /L
C) In smoldering myeloma plasma cells constitute 10 - 30% of total bone marrow cellularity
D) In a patient with multiple myeloma, a monoclonal light chain may be detected in both serum and urine
Answer:
Question 15: In-situ DNA nick end labeling can quantitate ?
A) Fraction of cells in apoptotic pathways
B) Fraction of cells in S phase
C) p53 gene product
D) bcr/abl gene
Answer:
Question 16: Which one of the following serum levels would help in distinguishing an acute liver disease from chronic liver disease ?
A) Aminotransferase
B) Alkaline phosphatase
C) Bilirubin
D) Albmin
Answer:
D
Question 17: Which one of the following stains is specific for Amyloid ?
A) Periodic Acid schiff (PAS)
B) Alzerian red
C) Congo red
D) Von-Kossa
Answer:
C
Question 18: Which one of the following diseases characteristically causes fatty change in liver ?
A) Hepatitis B virus infection
B) Wilson's disease
C) Hepatitis C virus infection
D) Chronic alcoholism
Answer:
D
Question 19: A 48 year old woman was admitted with a history of weakness for two months.
On examination, cervical lymph nodes were found enlarged and spleen was palpable
2 cm below the costal margin. Her hemoglobin was 10.5 g/dl, platelet count 237 X
109 / L and total leukocyte count 40 X 109 /L, which
included 80% mature lymphoid cells with coarse clumped chromatin. Bone marrow
revealed a nodular lymphoid infiltrate. The peripheral blood lymphoid cells were
positive for CD19, CD5, CD20, CD23 and were negative for CD79B and FMC-7. The
histopathological examination of the lymph node in this patient will most likely
exhibit effacement of lymph node architecture by ?
A) A pseudofollicular pattern with proliferation centers
B) A monomorphic lymphoid proliferation with a nodular pattern
C) A predominantly follicular pattern
D) A diffuse proliferation of medium to large lymphoid cells with high mitotic rate
Answer:
D
Question 20: The most common leukocytoclastic vasculitis affecting children is ?
A) Takayasu disease
B) Mucocutaneous lymph node syndrome (Kawasaki disease)
C) Henoch Schonelin purpura
D) Polyarteritis nodosa
Answer:
C
Question 21: A four year old boy was admitted with a history of abdominal pain and fever
for two months, maculopapular rash for ten days, and dry cough, dyspnea and
wheezing for three days. On examination, liver and spleen were enlarged 4 cm and
3 cm respectively below the costal margins. His hemoglobin was 10.0 g/dl,
platelet count 37 x 109/L and total leukocyte count 70 x 109/L,
which included 80% eosinophils. Bone marrow examination revealed a cellular
marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors.
The blasts stained negative for myeloperoxidase and non-specific esterase
and were positive for CD 19, CD 10, CD22 and CD20. Which one of the following
statements in not true about this disease ?
A) Eosinophils are not part of the neoplastic clone
B) t(5; 14) rearrangement may be detected in blasts
C) Peripheral blood eosinophilia may normalize with chemotherapy
D) Inv (16) is often detected in the blasts and the eosinophils
Answer:
Question 22: Kidney biopsy from a child with hemolytic uremic syndrome characteristically most likely presents features of ?
A) Thrombotic microangiopathy
B) Proliferative glomerulonephritis
C) Focal segmental glomerulosclerosis
D) Minimal change disease
Answer:
A
Question 23: The classification proposed by the International Lymphoma Study Group for non-Hodgkin's lymphoma is known as ?
A) Kiel classification
B) REAL classification
C) WHO classification
D) Rappaport classification
Answer:
Question 24: One of the intestinal enzymes that is generally deficient in children following an attack of severe infectous enteritis is ?
A) Lactase
B) Trypsin
C) Lipase
D) Amylase
Answer:
A
Question 25: A new born presetned with bloated abdomen shortly after birth with passing of less meconium. A full-thickness biopsy of the rectum was carried out. Which one of the following is most likely to be present ?
A) Fibrosis of submucosa
B) Hyalinisation of the muscular coat
C) Thickened muscularis propria
D) Lack of ganglion cells
Answer:
D
Question 26: All of the following features are seen in the viral pneumonia except ?
A) Presence of intersitial inflammation
B) Predominance of alveolar exudates
C) Bronchiolitis
D) Multinucleate giant cells in the bronchilar wall
Answer:
B
Question 27: Type I hypersensitivity is mediated by which of the following immunoglobulins ?
A) Ig A
B) Ig G
C) Ig M
D) Ig E
Answer:
D
Question 28: Which of the following is the most common location of hypertensive bleed in the brain ?
A) Putamen/external capsule
B) Pons
C) Ventricles
D) Lobar white matter
Answer:
A
Question 29: A woman with infertility receives an ovary transplant from her sister who is an identical Twin. What type of graft it is ?
A) Xenograft
B) Autograft
C) Allograft
D) Isograft
Answer:
D
Question 30: The following is not a feature of malignant transformation by cultured cells ?
A) Increased cell density
B) Increased requirement for growth factors
C) Alterations of cytoskeletal structures
D) Loss of anchorage
Answer:
B
Question 31: A simple bacterial test for mutagenic carcinogens is ?
A) Ames test
B) Redox test
C) Bacteriophage
D) Gene splicing
Answer:
A
Question 32: In Von Hippel-Lindau Syndrome, the retinal vascular tumors are often associated with intracranial hemangioblastoma. Which one of the following regions is associated with such vascular abnormalities in this syndrome ?