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Mechanism of Action of Bacterial Toxins


Mechanism of Action of Bacterial toxins
 
BacteriaMechanism of Action of Its Toxin
Diphtheria ToxinInhibiting Protein Synthesis (Inhibits elongation factor, thus prevents peptide chain elongation)
Cholera ToxinIncreased secretion from Mucosa
E. coli (LT of Enterotoxigenic E. coli)Increased secretion from Mucosa
Shiga toxinInhibiting Protein Synthesis
  • Shiga toxin is composed of 2 peptide subunits.
  • Subunit A - hydrolyzes adenine from rRNA of 60 S Subunit of mammalian ribosome, inhibiting protein synthesis irreversibly
  • Subunit B - recognizes glycolipids of target cell membranes
  • Note: Shiga toxin is encoded by iron-regulated chromosomal gene stx
Pertussis toxin
  • Mitogenic activity
  • Affects circulation of lymphocytes
  • Serves as an adhesin for bacterial binding to respiratory ciliated cells

References -
[Harrison's][Ananthanarayanan]

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