Home >> Study >> ForumTopic: CD MARKERS to be continued
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| Varunrag Total Posts: 72 | Posted: Fri Sep 19, 2008 07:29 am CD1a Langerhans cell histiocytosis CD2 T cell marker (although CD3 is more common), marker of systemic mastocytosis CD3 most specific T cell antibody; diminished expression in T cell cutaneous lymphoma CD4 classify lymphomas and inflammatory conditions; serum levels are marker of HIV disease progression and response to therapy (CD4+ cells are killed by HIV); serum levels also increased by transient stress CD5 marker for CLL, mantle cell lymphoma, T cells (normal and malignant), thymic carcinoma CD6 Antibodies to CD6 are used to deplete T cells from bone marrow transplants to prevent graft versus host disease CD8 cytotoxic T cell marker CD10 Acute lymphoblastic leukemia (ALL): Angioimmunoblastic T cell lymphoma: Breast: marker of myoepithelial cells Burkitt’s lymphoma: Diffuse large cell lymphoma: Ectopic prostate: Endometrial stromal tumors: Endometriosis: Follicular lymphoma: Gynecologic tumors: Hemangioblastoma |
| Varunrag Total Posts: 72 | Posted: Fri Sep 19, 2008 07:37 am CD11c histiocytic marker, NK cell marker, diagnosis of hairy cell leukemia (with other markers) CD13 myeloid marker CD14 mature monocytes/macrophages CD15 Hodgkin’s lymphoma CD16a NK cell and macrophage marker; to subtype leukemia/lymphoma CD19 Earliest B cell antigen in fetal tissue CD20 commonly used marker for B cells |
| Varunrag Total Posts: 72 | Posted: Fri Sep 19, 2008 07:46 am CD21 Binds to Epstein Barr virus (EBV) and HHV8 ,diagnose follicular dendritic cell sarcomas CD22 Also called B lymphocyte cell adhesion molecule (BL-CAM) CD23 Mantle cell lymphoma: usually CD23 negative , Also known as low affinity IgE receptor, Fc fragment of IgE receptor, FCER CD24 strong expression is a poor prognostic factor in colorectal carcinoma , nonsmall cell lung carcinoma , ovarian cancer , intrahepatic cholangiocarcinom CD30 confirm diagnosis of anaplastic large cell lymphoma, classic Hodgkin’s lymphoma, embryonal carcinoma |
| jemzcal Total Posts: 127 | Posted: Fri Sep 19, 2008 08:29 am good work |
| Varunrag Total Posts: 72 | Posted: Fri Sep 19, 2008 08:32 am CD31 Platelet endothelial cell adhesion molecule, PECAM-1--confirms vascular origin of tumors CD33 Classic myeloid antigen (also CD13) CD34 adult hematopoietic stem cells --Kaposi’s sarcoma,epithelioid sarcoma CD38 dentify plasma cells and plasmablastic differentiation, diagnosis of myeloma, prognosis for CLL patient CD41 Also called platelet GPIIb----identify platelets or megakaryocytes ,isolate platelets , confirm diagnosis of AML-M7, diagnose Glanzmann thrombasthenia CD42a Also called platelet glycoprotein GPIX and GP9 CD42b Also called platelet GPIb alpha, glycoprotein Ib-alpha CD42c Also called platelet GPIb beta, glycoprotein Ib-beta CD42d Also called platelet GP V CD45 Also called leukocyte common antigen (LCA), protein tyrosine phosphatase CD48 Also called Blast-1 Glycosyl phosphatidylinositol (GPI) anchored surface molecule To diagose PNH |
| Varunrag Total Posts: 72 | Posted: Fri Sep 19, 2008 07:11 pm CD52 antibodies (Alemtuzumab) are used for long-term depletion of T lymphocytes from donor marrow to prevent graft versus host disease ,also to treat refractory CLL; high serum levels are poor prognostic marker in CLL , may treat other malignancies , including pure red blood cell aplasia CD55 Also called complement decay accelerating factor (DAF) Uses: diagnosis of PNH CD56 Also called N-CAM (neural cell adhesion molecule) Uses: marker for NK cells and NK lymphomas; differentiates plasma cells in myeloma (CD56+) from reactive plasmacytosis or MGUS CD57 Uses: marker of NK cells and neuroendocrine tumors |
| Varunrag Total Posts: 72 | Posted: Fri Sep 19, 2008 07:22 pm CD61 Uses: identify platelets, megakaryocytes, platelet thrombi; distinguish TTP from DIC CD62P heparin-induced thrombocytopenia CD63 marker of melanoma (although non-specific) and melanocytic tumors CD64 high neutrophil CD64 levels predict sepsis CD65 myeloid antigen CD66e Also called CEA, carcinoembryonic antigen HOPE ALL KNOW THE USES CD71 Also known as transferrin receptor Uses: high serum levels can diagnose hemolytic anemia CD79a Uses: general detection of B cells/B cell origin (with CD20); also - in ALL or small B cell lymphoproliferative disorders when CD20 may be negative or after rituximab (anti CD-20) therapy CD79b Uses: distinguish CLL from other B cell disorders if intensity of staining is considere |
| Varunrag Total Posts: 72 | Posted: Fri Sep 19, 2008 07:28 pm CD83 marker for activated dendritic cells CD90 Also called Thy-1 Uses: hematopoietic stem cell marker CD95 Also called Fas, Apo-1, TNF receptor superfamily member 6, TNFRSF6 Cell surface membrane receptor that activates apoptotic pathways when bound by Fas ligand (FasL, CD178 CD99 relatively non-specific marker for Ewing’s sarcoma and T cell lymphoma, but does distinguish Ewing’s from neuroblastoma |
| Varunrag Total Posts: 72 | Posted: Sat Sep 20, 2008 06:47 am CD103 marker for hairy cell leukemia, intraepithelial lymphocytes (normal or tumor) CD105 specific and sensitive marker for tumor angiogenesis CD107b cardiomyopathy due to Danons disease CD117 GIST CD238 Kell blood group antigen CD239 Lutheran blood group antigen; B-CAM CD240 CE Also called RH 30 CE, Rh blood group Cc and Ee blood group antigens CD240 D Also called RH30 D, Rh blood group D blood group antigen; is major antigen of the Rh system CD281 TLR1_HUMAN CD282 TLR2_HUMAN TLR--toll like receptor CD283 TLR3_HUMAN CD284 TLR4_HUMAN CD289 TLR9_HUMAN |
| Varunrag Total Posts: 72 | Posted: Sat Sep 20, 2008 06:48 am PLEASE ADD MORE MARKERS.......... |
| nimit Total Posts: 7 | Posted: Sun Sep 21, 2008 01:23 am pls do inform me |
| poulomi Total Posts: 15 | Posted: Sat Sep 27, 2008 07:38 pm Absolutely brilliant.  |
| varuchinu Total Posts: 44 | Posted: Tue Oct 21, 2008 06:57 pm CD 43 --Wiskott Aldrich syndrome. CD 25 ,CD 127 -- Multiple sclerosis. CD 23 -- Atopic dermatitis. |
| Varunrag Total Posts: 72 | Posted: Tue Oct 21, 2008 08:33 pm CD 18 : LAD 1 E Selectin LAD 2 |
| varuchinu Total Posts: 44 | Posted: Wed Oct 22, 2008 02:40 am hi varunrag, gr8 job! . gr8 time management !0.04 sec/qn ... tat too consistently.. could u kindly tell how long we can afford to spend for 300 questions with explanations [all india paper ].kindly help out .
Thanks in advance . |
| Varunrag Total Posts: 72 | Posted: Wed Oct 22, 2008 02:57 am No dear ... I am doing this from my mobile . Thats why that time disparity !!! |
| superbdoc Total Posts: 273 | Posted: Wed Oct 22, 2008 02:57 pm LOL...that solves that problem too....  |
| abkalavant Total Posts: 6 | Posted: Wed Oct 29, 2008 01:20 pm cellular receptors for measles in human leucocytes and other cells is CD40 & CD150 [Ref: Harrisons16 Pg1148 |
| superbdoc Total Posts: 273 | Posted: Thu Jan 15, 2009 05:22 pm While it is abundant in extracellular matrices, hyaluronan also contributes to tissue hydrodynamics, movement and proliferation of cells, and participates in a number of cell surface receptor interactions, notably those including its primary receptor, CD44. Upregulation of CD44 itself is widely accepted as a marker of cell activation in lymphocytes. Hyaluronan's contribution to tumor growth may be due to its interaction with CD44. Receptor CD44 participates in cell adhesion interactions required by tumor cells |