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| superbdoc Total Posts: 273 | Posted: Tue Sep 30, 2008 03:35 pm Dexamethasone suppression test Metyrapone test Co-Syntropin test Please can someone provide me with knowledge resource to these 3 tests..and that too Quick facts worth remembering..  |
| superbdoc Total Posts: 273 | Posted: Tue Sep 30, 2008 09:52 pm Anyone willing to help..??  |
| jemzcal Total Posts: 127 | Posted: Tue Sep 30, 2008 11:17 pm all three tests are done to see the working of the HPA-ADRENALCORTEX system. 1) cosyntropin - it is a derivative of ACTH. so upon giving it the cortisol levels should increase. we measure the cortisol levels after the test and see if there is a failure on the part of adrenal cortex to secrete cortisol 2) Metyrapone - it is an inhibitor of 11b hydroxylase, the enzyme needed in cortisol synthesis. so when we give metyrapone, the cortisol production stops. Sensing this a normally working HPA should secrete ACTH. we measure this and see if the pituitary is working properly. 3) Dex supp test - there are two variants of this test.low dose and high dose. in a normal person, the HPA is suppressed on giving sux and sence cortisol levels will be low after giving it.If a person is having a pituitary tumour or an ectopic source of ACTH, it wont be suppressed with a low dose sux. to distinguish the two we do a high dose test where in the former condition it will be suppressed. ** remember cosyntropin is a derivative of Adreno corticotropin hormone |
| jemzcal Total Posts: 127 | Posted: Tue Sep 30, 2008 11:22 pm dex sup'n test low dose high dose normal suppress suppress adrenal tumour no no pituitary tumour no suppress ectopic ACTH no no to differentiate the 2nd and 4th condition we can measure the ACTH levels, which will obviously be high in the ectopic source. |
| superbdoc Total Posts: 273 | Posted: Wed Oct 01, 2008 02:09 pm your help is well appreciated...  |