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| mickey7 Total Posts: 25 | Posted: Sat Jul 11, 2009 08:47 pm what is balkan nephropathy |
| juhidr Total Posts: 149 | Posted: Sun Jul 12, 2009 01:45 am Balkan Endemic Nephropathy (BEN) is a tubulointerstitial kidney disease which final stage is characterized by renal failure and shrinkage of both kidneys. Cases of BEN were first described in Bulgaria in 1956. In 1964, this disease was recognized as a new nosological entity, although its causes are still unknown. Although this disease is endemic in rural areas of the Balkan, endemic nephropathies are reported to occur in other regions too. For instance, chronic kidney diseases of uncertain etiology, which resemble BEN, have been reported in Sri Lanka. In the past 50 years, etiologic explanations have emerged emphasizing for instance lignites or organic substances from coal, aristolochic acid, ochratoxin A, metals, and metalloids. However, these claims are often not substantiated by sufficient evidence or scientific studies. Established BEN is characterized by marked tubulointerstitial fibrosis and tubule atrophy without evidence of significant inflammatory cell infiltration. |