| A. Autosomal Dominant Conditions | ||
| BRCA-1 | Mutation of Chr. 17q | Malignancies of Breast, Ovary, Prostate, Colon |
| BRCA-2 | Mutation of Chr. 13q | Malignancies of Breast (including male), Ovary, Prostate, Pancreas, Larynx |
| Li-Fraumeni Syndrome | Mutation in Chr. 17p (p53 gene) | Malignancies of Breast, Brain, Adrenals, Soft tissue sarcomas |
| Muir-Torre Syndrome | Mutation in Chr. 2p (Mismatch repair genes hMLH1, hMSH2) | Malignancies of Breast, GI and Genitourinary Tract, Sebaceous tumors, Keratoacanthoma |
| Cowden Disease | Mutation in Chr. 10q (PTEN gene) | Malignancies of Breast, Bladder, Colon, Uterus, Thyroid, Lung, Hamartomatous polyps in GIT |
| Peutz-Jeghers Sydrome | Mutation in Chr. 19p (STK11 gene) | Malignancies of Breast, Pancreas, Hamartomas in GIT, Mucocutaneous melanin deposition |
| B. Autosomal Recessive Conditions | ||
| Ataxia telangiectasia | ||